Robustified MANOVA with applications in detecting differentially expressed genes from oligonucleotide arrays

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Robustified MANOVA with applications in detecting differentially expressed genes from oligonucleotide arrays

MOTIVATION Oligonucleotide arrays such as Affymetrix GeneChips use multiple probes, or a probe set, to measure the abundance of mRNA of every gene of interest. Some analysis methods attempt to summarize the multiple observations into one single score before conducting further analysis such as detecting differentially expressed genes (DEG), clustering and classification. However, there is a risk...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2008

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btn053